Veröffentlichungen Teilprojekt D2 - Nerven-Elektroden-Interaktion

Referierte Publikationen:


Pooyan Aliuos, Uta Reich, Elena Fadeeva, Mohammad Badar, Andreas Winkel, Peter P. Mueller, Athanasia Warnecke, Boris Chichkov, Thomas Lenarz, Guenter Reuter. Evaluation of Single Cell Force Spectroscopy and Fluorescence Microscopy to Determine Cell Interactions with Femtosecond Laser Micro-structured Titanium Surfaces. Manuscript id: JBMR-A-12-0458


Reich U, Fadeeva E, Warnecke A, Paasche G, Müller P, Chichkov B, Stöver T, Lenarz T, Reuter G. Directing neuronal cell growth on implant material surfaces by microstructuring. J Biomed Mater Res B Appl Biomater. 2012 Jan 30. doi: 10.1002/jbm.b.32656.


Neuheiser, A., Lenarz, M., Reuter, G., Calixto, R., Nolte, I., Lenarz, T. & Lim, H. H.. Effects of pulse phase duration and location of stimula­tion within the inferior colliculus on auditory cortical evoked potentials in a guinea pig model. JARO (accepted, Juli 2010).


Warnecke A, Sasse S, Wenzel GI, Hoffmann A, Gross G, Paasche G, Scheper V, Reich U, Esser KH, Lenarz T, Stöver T, Wissel K.  Stable release of BDNF from the fibroblast cell line NIH3T3 grown on silicone elastomers enhances survival of spiral ganglion cells in vitro and in vivo. Hear Res. 2012 Jul;289(1-2):86-97.


Kontorinis G, Scheper V, Wissel K, Stöver T, Lenarz T, Paasche G. In vitro modifications of the scala tympani environment and the cochlear implant array surface. Laryngoscope. 2012 May 30. doi: 10.1002/lary.23408.


A. Neuheiser, M. Lenarz, G. Reuter, R. Calixto, I. Nolte, T. Lenarz, H.H. Lim (2010)
Effects of pulse phase duration and location of midbrain stimulation on cortical evoked potentials in a guinea pig model JARO (published online18. August 2010, Volume 11, Issue 4 (2010), 689 699


P. Aliuos, E.Fadeeva, S. Gollapudi, B.Chichkov, U. Klug, T. Lenarz, U. Reich, G. Reuter Untersuchung der Adhäsionskräfte von Fibroblasten auf Mikrostrukturierten Oberflächen Mittels Rasterkraftmikroskopie (AFM) Biomed Tech 2010; 55 pp


T. Lenarz, U. Reich, A. Warnecke, R. Calixti, P.Aliuos, K. Wissel. B. Chichkov, E. Fadeeva, G. Gross, A. Hoffmann, H. Wenzel, W. Dempwolf, A. Sen, G. Reuter, Nerven-Elektroden-Interaktion . Herausgeber T.Lenarz, F-W. Bach, I. Nolte, Zukunftsfähige bioresorbierbare und permanente Implantate aus metallischen und keramischen Werkstoffen. ISBN 978-3-00-032924-1S. 27-45


Kramer, F., Stover, T., Warnecke, A., Diensthuber, M., Lenarz, T. & Wissel, K. (2010). BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. J Neurooncol 98, 31-9.


Aliuos, P., Fadeeva, E., Gollapudi, S., Reuter, G., Chichkov, B. N., Klug, U., Lenarz, T. & Reich, U. (2009). Cell adhesion studies on laser modified silicon and silicone. Biomaterialien 10.


Fadeeva, E., Schlie, S., Koch, J., Chichkov, B. N., Vorobye, A. Y. & Guo, C. (2009a). Femtosecond laser-induced surface structures on platinum and their effects on wettability and fibroblast cell proliferation. Contact Angle, Wettability and Adhesion 6.


Fadeeva, E., Schlie, S., Koch, J., Ngezahayo, A. & Chichkov, B. N. (2009b). The hydrophobic properties of femtosecond laser fabricated spike structures and their effects on cell proliferation. Phys. Status Solidi 206, 6.


Lenarz, T., Lim, H., Joseph, G., Reuter, G. & Lenarz, M. (2009). [Central audi­tory prosthesis]. HNO 57, 551-62.


Lim, H. H., Lenarz, M. & Lenarz, T. (2009). Auditory midbrain implant: a review. Trends Amplif 13, 149-80.


Reich, U., Aliuos, P., Fadeeva, E., Gollapudi, S., Klug, U., Kling, R., Chichkov, B. N., Lenarz, T. & Reuter, G. (2009). Cell growth and adhesion on micro structured cochlear implant materials. Biomaterialien 10.


Schlie, S., Fadeeva, E., Koch, J., Ngezahayo, A. & Chichkov, B. N. (2009). Fem tosecond Laser Fabricated Spike Structures for Selective Control of Cellu­lar Behavior. J Biomater Appl2009; doi:10.1177/0885328209345553


Lim, H. H., Lenarz, T., Anderson, D. J. & Lenarz, M. (2008a). The auditory mid­brain implant: effects of electrode location. Hear Res 242, 74-85.


Lim, H. H., Lenarz, T., Joseph, G., Battmer, R. D., Patrick, J. F. & Lenarz, M. (2008b). Effects of phase duration and pulse rate on loudness and pitch per­cepts in the first auditory midbrain implant patients: Comparison to cochlear implant and auditory brainstem implant results. Neuroscience 154, 370-80.


Reich, U., Fadeeva, E., Gollapudi, S., Chichkov, B. N., Klug, U., Kling, R., Lenarz, T. & Reuter, G. (2008a). Einfluss der Mikrotopographie auf das in vitro-Aufwachsverhalten von Fibroblasten. Biomaterialien 9.


Reich, U., Mueller, P. P., Fadeeva, E., Chichkov, B. N., Stoever, T., Fabian, T., Lenarz, T. & Reuter, G. (2008b). Differential fine-tuning of cochlear implant material-cell interactions by femtosecond laser microstructuring. J Biomed Ma­ter Res B Appl Biomater 87, 146-53.


Torkos, A., Wissel, K., Warnecke, A., Lenarz, T. & Stover, T. (2008). Techni­cal report: laser microdissection and pressure catapulting is superior to con­ventional manual dissection for isolating pure spiral ganglion fractions from the cochlea. Hear Res 235, 8-14.


Wissel, K., Stover, T., Hofmann, N. S., Chernajovsky, Y., Daly, G., Sasse, S., Warnecke, A., Lenarz, T., Gross, G. & Hoffmann, A. (2008). Fibroblast-mediated delivery of GDNF induces neuronal-like outgrowth in PC12 cells. Otol Neurotol 29, 475-81.


Fadeeva, E., Schlie, S., Koch, J. & Chichkov, B. N. (2007). Femtosekundenlaser­basierte Techniken zur Oberflächenfunktionalisierung von medizinischen Implantaten. Biomaterialien 8.


Lenarz, M., Lim, H. H., Lenarz, T., Reich, U., Marquardt, N., Klingberg, M. N., Paasche, G., Reuter, G. & Stan, A. C. (2007). Auditory midbrain implant: his­tomorphologic effects of long-term implantation and electric stimulation of a new deep brain stimulation array. Otol Neurotol 28, 1045-52.


Lim, H. H., Lenarz, T., Joseph, G., Battmer, R. D., Samii, A., Samii, M., Patrick, J. F. & Lenarz, M. (2007). Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central audi­tory system. J Neurosci 27, 13541-51.


Reich, U., Reuter, G., Fadeeva, E., Chichkov, B. N., Warnecke, A., Stöver, T. & Lenarz, T. (2007). Gerichtetes Wachstum neuronaler Zellen auf mikrostruktu­riertem Implantatmate-rial. Biomaterialien 8, 162.


Samii, A., Lenarz, M., Majdani, O., Lim, H. H., Samii, M. & Lenarz, T. (2007). Auditory midbrain implant: a combined approach for vestibular schwannoma surgery and device implantation. Otol Neurotol 28, 31-8.


Warnecke, A., Wissel, K., Hoffmann, A., Hofmann, N., Berkingali, N., Gro, G., Lenarz, T. & Stover, T. (2007). The biological effects of cell-delivered brain-derived neurotrophic factor on cultured spiral ganglion cells. Neuroreport 18, 1683-6.


J. Koch, E. Eadeeva, M. Engelbrecht, C. Ruffert, H.H. Gatzen, A. Ostendorf, B.N. Chichkov: Maskless nonlinear lithography with femtosecond laser pulses. Appl. Phys. A 2006, 82: 23–26


M. Lenarz, H.H. Lim, J.F. Patrick, D.J. Anderson, T. Lenarz: Electrophysiological validation of a human prototype auditory midbrain implant (AMI) in a guinea pig model. J Assoc Res Otolaryngol. 2006 Dec;7(4):383-98.


T. Lenarz, H.H. Lim, G. Reuter, J.F. Patrick, M. Lenarz: The auditory midbrain implant: A new auditory prosthesis for neural deafness concept and device description. Otol Neurotol. 2006 Sep;27(6):838-43


G. Paasche, L. Bögel, M. Leinung, T. Lenarz, T. Stöver: Substance distribution in a cochlea model using different pump rates for cochlear implant drug delivery electrode prototypes. Hear Res. 2006, 212 (1-2): 74-82 


U. Reich, G. Reuter, P. Müller, T. Stöver, T. Fabian, B. Chichkov, T. Lenarz: Fibroblasts and neuronal precursor cells on micro structured implant materials. Biomaterialien 2006, 7 (3):209


G. Reuter, T. Lenarz Hearing Implants, 39th Annual Congress of the German Society for Biomedical Engineering BMT 2005, Nürnberg, Germany, Biomedizinische Technik 50, Teil 1-2, 806-807 


G. Reuter, A. Stan, U. Reich, N. Marquardt, M.-N. Klingberg, G. Paasche, J. Patrick, T. Lenarz, M. Lenarz: Histologische Untersuchungen des Colliculus inferior nach chronischer elektrischer Stimulation. Biomaterialien in der Hals-Nasen-Ohrenheilkunde, Rostock 2005, Biomaterialien 6, 38-39


T. Stöver, N. Hofmann, A. Hoffmann, G. Gross, G. Paasche, T. Lenarz: Neuronal differentiation induced by transgenic cells expressing neurotrophic factors on the surface of cochlea implant materials, Biomaterialien 7 (S1), 2006: 119.


T. Stöver, P. Issing, G. Graurock, P. Erfurt, Y. ElBeltagy, G. Paasche, T. Lenarz: Evaluation of the advance off-stylet insertion technique and the cochlear insertion tool in temporal bones. Otol Neurotol. 2005, 26 (6): 1161-1170 


P. Wefstaedt, V. Scheper, T. Lenarz, T. Stöver: Brain-derived neurotrophic factor/glial cell line-derived neurotrophic factor survival effects on auditory neurons are not limited by dexamethasone. Neuroreport. 2005, 16 (18): 2011-2014 


T. Lenarz, A. Büchner, G. Reuter, M. Lenarz, T. Stöver: Neue Elektrodensysteme für Cochlea-Implantate und Auditorische Hirnstammimplantate, 38. Jahrestagung der Deutsche Gesellschaft für Biomedizinische Technik im VDE , Ilmenau 2004, p. 894-895 


G. Reuter, U. Reich, N. Marquardt, M.-N. Klingberg, M. Lenarz, Th. Lenarz: Frequency-Specific Activity of the Auditory Pathway with Auditory Midbrain Implants. 38. Jahrestagung der Deutsche Gesellschaft für Biomedizinische Technik im VDE , Ilmenau 2004, p. 896-897 


G. Paasche G, P. Gibson, T. Averbeck, H. Becker, T. Lenarz, T. Stöver: Technical report: modification of a cochlear implant electrode for drug delivery to the inner ear. Otol Neurotol. 2003, 24(2): 222-227



T. Lenarz, G. Reuter: Auditorische Implantate in: Mikrosysteme in der Medizin. Hrsg.: K-P. Hoffmann, J. Dehm, ISBN 3-00-017424-9; 2005, 36-47 


Lim, H. H., Lenarz, M. & Lenarz, T. (June 2009). A New Auditory Prosthesis Using Deep Brain Stimulation: Development and Implementation Implantable Neural Prostheses 1: Devices and Applications ISBN: 978-0-387-77260-8, DOI: 10.1007/978-0-387-77261-5_4,


Lenarz, T., Lim, H. H. & Lenarz, M. (June 2008). Recent Advances in Otolaryngol­ogy, The Auditory Midbrain Implant: Experimental and clinical re­sults, The Royal Society of Medicine Press as part of the Recent Advances Se­ries, ISBN: 1853157112,



N. Hofmann: Posterpreis zur 77. Jahrestagung der Deutsche Gesellschaft für Hals-, Nasen- Ohrenheilkunde, Mannheim 2006. 1. Preis


U. Reich: Förderpreis der Deutschen Gesellschaft für Audiologie (DGA) 2006